Colorectal Cancer Treatments and Studies

SEP 10, 2026 · JOURNAL ARTICLE

Sterile neutrophilic pseudomembranous conjunctivitis associated with tisotumab vedotin: clinical and cytological evidence from two cases

BMC Ophthalmology

Two uncontrolled case reports describing a newly recognized adverse effect of tisotumab vedotin, with cytological mechanistic insight but no comparative data or systematic incidence assessment.

SEP 9, 2026 · JOURNAL ARTICLE

Molecularly informed preoperative and response-adapted management of colorectal cancer: evidence, decision boundaries, and emerging directions

Frontiers in Oncology

This is a narrative review synthesizing evidence across multiple preoperative colorectal cancer strategies, providing decision boundaries and clinical recommendations rather than reporting original trial data.

SEP 8, 2026 · JOURNAL ARTICLE

High frequency of NRAS mutations and RAS co-mutations in colorectal cancer from the Kurdistan region of Iraq: molecular and survival analysis

Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale

A small, single-centre molecular profiling study from an underrepresented population reporting mutation frequencies and survival associations, without a comparator arm or randomization, that the authors themselves flag as requiring larger validation.

SEP 8, 2026 · REVIEW

Clinical activity of chidamide-containing regimens after prior PD-1-based therapy in two patients with microsatellite-stable metastatic colorectal cancer: a case series and narrative review

Frontiers in Oncology

A two-patient retrospective case series with mixed responses (one PR, one SD) in a heavily pretreated population; descriptive observations that generate hypotheses rather than test them and are explicitly insufficient to demonstrate efficacy or resistance reversal.

SEP 7, 2026 · JOURNAL ARTICLE

Structural classification of EGFR mutations and its association with TKI efficacy against compound and co-mutations in a Chinese NSCLC cohort: a single-center retrospective analysis

BMC Cancer

A single-center retrospective cohort study with clear findings on EGFR mutation subtypes and TKI sensitivity in a defined population, but limited by retrospective design, lack of survival or clinical outcome detail, and modest sample sizes for the key comparison groups.

SEP 6, 2026 · JOURNAL ARTICLE

Multivariate survival analysis of patients with stage III–IV colon cancer: clinical and biological factors and the impact of treatment regimen

South Russian Journal of Cancer

Retrospective single-centre cohort with modest follow-up (1.4 years median) and no randomization; observational associations with biomarkers and treatment types are hypothesis-generating rather than definitive.

SEP 4, 2026 · JOURNAL ARTICLE

Benmelstobart plus antiangiogenic therapy vs chemotherapy for metastatic triple-negative breast cancer: phase III trial

npj Breast Cancer

Underpowered trial prematurely stopped at 46% of planned enrollment with non-significant primary endpoint; efficacy analyses explicitly stated as exploratory, requiring cautious interpretation.

SEP 4, 2026 · JOURNAL ARTICLE

A Phase 1 Study of PF-07062119, an Anti-GUCY2C/Anti-CD3 Bispecific Fc Antibody, in Patients With Advanced Gastrointestinal Cancers

Cancer Research Communications

First-in-human Phase 1 dose escalation with primary focus on safety and tolerability; anti-tumor activity is secondary and minimal (2.5% ORR), consistent with early-phase exploratory work.