AI Summary

Everything in the life sciences, grouped by what the evidence is rather than when it landed.

How to read the grades

PromisingEncouraging direction, but not yet definitive.

Expert GuidanceA consensus or society position rather than new primary data.

PreliminaryEarly or partial results. Treat as a signal, not a conclusion.

There is no combined score. Each item is graded across study design, directness, consistency, risk of bias and sample adequacy, and every rating carries its reasoning on the item’s own page.

Guidelines & Regulatory Updates 5

Official positions and label changes. Authoritative rather than novel.

The Lancet. Planetary Health · Journal article

Ecological-collective-flourishing (e-co-flourishing): a framework to guide innovation and research.

A conceptual framework proposing e-co-flourishing as an integrative approach to wellbeing across human and ecological systems, with illustrative application but no empirical outcome data or comparative evidence.

Expert Guidance

The Lancet. Microbe · Journal article

Advances in tuberculosis diagnostics and biomarkers, 2020-26: scientific evidence, recommendations, gaps, and developmental priorities.

This is a WHO policy synthesis and scientific evidence review consolidating diagnostic and biomarker advances from 2020–25, informing updated recommendations for TB detection and drug resistance across populations and specimen types.

Expert Guidance

The Lancet. Microbe · Journal article

Advances in tuberculosis treatment: novel regimens, new drug pipelines, host-directed therapies, and updated management guidelines.

A comprehensive narrative review synthesizing pivotal trial evidence and WHO guideline updates on tuberculosis treatment innovation since 2020, without reporting new primary efficacy data.

Expert Guidance

The Lancet. Microbe · Journal article

Minimal supply chain and forecasting testing volumes for clinical bacteriology laboratories in resource-limited settings for individual patient care: a costing study.

A costing model informed by expert consensus and real-world data from two African laboratories, providing evidence-based cost estimates and procurement guidance for implementing clinical bacteriology in resource-limited settings, without comparative effectiveness or outcome data.

Expert Guidance

The Lancet. Microbe · Journal article

Advances in development of tuberculosis vaccines and preventive drug therapies: current pipeline, evidence, and access.

A narrative review synthesizing current evidence on TB vaccine pipelines and preventive therapies, providing clinical and policy guidance rather than reporting primary efficacy data.

Expert Guidance

New Evidence in Topics You Follow 2

Solid additions to the areas you track.

Annals of Oncology · Journal article

Thymic Radiation is Associated with Worse Outcomes in Patients with NSCLC.

Multicohort observational analysis with consistent dose-response associations across three independent cohorts and plausible biological mechanism, but lacks randomized evidence of thymus-sparing intervention efficacy.

Promising

The Lancet. Global Health · Journal article

Cost-effectiveness of providing pre-exposure and post-exposure prophylaxis for the prevention of HIV via online pharmacies in western Kenya: a modelling study.

Modelling study projecting cost-effectiveness of online PrEP/PEP in western Kenya with favourable ICER under local threshold, but evidence strength limited by reliance on simulation, pilot data, and absence of real-world implementation outcomes.

Promising

Trials to Watch 2

Early or partial readouts. Direction, not conclusions.

Pakistan Journal of Pharmaceutical Sciences · Journal article

Britanin improved high-fat diet-induced obesity by regulating the MAPK signaling pathway.

Single-center animal study with mechanistic validation but no human data, uncontrolled design, and surrogate endpoints only; insufficient for clinical guidance despite sound experimental approach.

Preliminary

The Lancet. Planetary Health · Journal article

Mechanisms underpinning flourishing at the interface of humans and other natural entities: an umbrella review.

Umbrella review synthesizing nine systematic reviews on ecological-collective-flourishing mechanisms; evidence for causality is weak, largely cross-sectional and qualitative, with no examination of reciprocal human-non-human effects.

Preliminary

Also Published 111

Records where the abstract did not support a firm read.

Journal of Scientific Research and Reports · Oct 24, 2026 · Journal article

Silk Proteins in Cancer Nanomedicine: Drug Delivery, Tumour Targeting and Emerging Theranostic Platforms

Genome Medicine · Oct 24, 2026 · Journal article

Spatial transcriptomics landscape of livers from patients with metabolic dysfunction-associated steatohepatitis

Tropical Doctor · Oct 24, 2026 · Journal article

Endogenous panophthalmitis in a patient with diabetic kidney disease on haemodialysis: A vision-threatening manifestation of systemic infection

BMC Geriatrics · Oct 24, 2026 · Journal article

Structural compatibility between β‐lactams and substrate binding pockets of IMP ‐1 and NDM ‐1 determines the substrate spectrum

Journal of Clinical Oncology · Oct 24, 2026 · Journal article

ENZARAD (ANZUP 1303): Phase 3 Trial of Enzalutamide With Androgen Deprivation Therapy and Radiation Therapy in High-Risk Localized or Locally Advanced Prostate Cancer

eBioMedicine · Oct 24, 2026 · Journal article

Lipid dynamics and cardiovascular risk profiles on carbohydrate- or saturated fat-based diets: secondary analysis of the CARBFUNC trial

Reviews in Medical Virology · Oct 24, 2026 · Journal article

High prevalence of TROP2 expression identifies EBV-positive gastric cancer as a candidate for TROP2-directed antibody–drug conjugates

Molecular Pharmaceutics · Oct 24, 2026 · Journal article

Development of a 18F-Radiolabeled CD38 Probe for Targeted PET Imaging of NSCLC Xenografts with Different EGFR-Mutant Status

BMC Microbiology · Oct 24, 2026 · Journal article

The efficacy and safety of camrelizumab combined with apatinib for neoadjuvant therapy in locally advanced differentiated thyroid cancer

Nature Communications · Oct 24, 2026 · Journal article

Coordinated regulation of nuclear integrity and STING trafficking by miR-30d suppresses innate immunity in breast cancer

ClinicalTrials.gov · Oct 23, 2026 · Phase 1 Trial

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC36 Tablets for Oral Use in Adult Participants With Obesity or Overweight

ClinicalTrials.gov · Oct 23, 2026 · Phase 2 Trial

A Randomized, Open-Label, 52-Week Extension Study to Evaluate the Maintenance of Remission, Relapse Prevention, and Long-Term Safety of CreNeuroS™ in Patients With Major Depressive Disorder Who Achieved Remission Following an 8-Week Parent Study

Frontiers in Oncology · Oct 23, 2026 · Journal article

Accelerator-based BNCT as a drug–device regimen: system engineering, clinical evidence, and regulatory considerations

ClinicalTrials.gov · Oct 23, 2026 · Phase 1/2 Trial

Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer

Medicine · Oct 23, 2026 · Journal article

Efficacy and safety of GLP-1 receptor agonists in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)

ClinicalTrials.gov · Oct 23, 2026 · Phase 2 Trial

Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and Sepsis

ClinicalTrials.gov · Oct 23, 2026 · Phase Early Phase 1 Trial

Postprandial Profiles of Metabolites and Appetite-regulating Hormones in Plasma and Cerebrospinal Fluid

Communications Biology · Oct 23, 2026 · Journal article

Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinoma

ClinicalTrials.gov · Oct 23, 2026 · Phase 2/3 Trial

Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC)

International Journal of Multidisciplinary Research Updates · Oct 23, 2026 · Journal article

Heavy Metal Burden in Prostate Cancer Patients: A Comparative Analysis of Selenium, Cadmium, Aluminum, Lead, Iron, and Mercury Across Treatment Stages Using ICP Technique

International Journal of Molecular Sciences · Oct 23, 2026 · Journal article

Tissue-resolved transcriptomic and proteomic profiling reveals organ-specific molecular signatures associated with inter-animal variation in glycemic response to metformin in obese diabetic Mongolian gerbils

ClinicalTrials.gov · Oct 23, 2026 · Interventional Study

REM Sleep Disruption and Its Potential Uses in Depression Management

Infectious Diseases and Therapy · Oct 23, 2026 · Journal article

Rise of Lower Respiratory Tract Infections Other than Respiratory Syncytial Virus in the Emergency Room: Results from the Season (2024/25) of the RISE Study

Revista Fisio&terapia. · Oct 23, 2026 · Journal article

Periodização de treinamento resistido para pacientes em uso de Tirzepatida: modelo de preservação muscular e adaptação neuromecânica (12 semanas).

ClinicalTrials.gov · Oct 23, 2026 · Interventional Study

The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.

ClinicalTrials.gov · Oct 23, 2026 · Phase 1/2 Trial

VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study in Participants With Early Alzheimer's Disease

ClinicalTrials.gov · Oct 23, 2026 · Interventional Study

Pacing in Heart Failure With Preserved LVEF

Cancer · Oct 23, 2026 · Journal article

Body mass index at diagnosis, postdiagnosis change, and role of metabolic comorbidities in relation to survival in nonmetastatic renal cell carcinoma patients

Frontiers in Oncology · Oct 23, 2026 · Review

The effectiveness of virtual reality–assisted relaxation therapy in improving psychological symptoms and fatigue of breast cancer survivors: a systematic review and meta-analysis

Jpgn Reports · Oct 23, 2026 · Journal article

A rare diagnosis during evaluation for metabolic dysfunction associated steatotic liver disease: Glycogen storage disease type Ia presenting during adolescence in a male with severe obesity

ClinicalTrials.gov · Oct 23, 2026 · Interventional Study

A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

JAMA · Oct 23, 2026 · Journal article

Trastuzumab Rezetecan in ERBB2-Low Advanced Breast Cancer

Langmuir · Oct 23, 2026 · Journal article

NIR-Responsive CoSn(OH)6/CuS Heterostructure Microneedles Integrate ROS and H2S Generation with Tanshinone IIA Delivery for Breast Cancer Therapy

Quantitative Imaging in Medicine and Surgery · Oct 23, 2026 · Review

Superiority of magnetic resonance elastography and proton density fat fraction: an umbrella meta-analysis of non-invasive imaging for hepatic steatosis and fibrosis in metabolic dysfunction-associated steatotic liver disease and chronic hepatitis B

Discover Nano · Oct 23, 2026 · Journal article

Predictive Value of Serum Spexin for Poor Glycemic Control and Its Relationship with Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

Georgetown Medical Review · Oct 23, 2026 · Journal article

Comparative Effects of Metformin and GLP-1 Agonists on Polyendocrine Metabolic Ovary Syndrome and Gallbladder Disease

ClinicalTrials.gov · Oct 23, 2026 · Interventional Study

Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health

Frontiers in Cell and Developmental Biology · Oct 23, 2026 · Journal article

Cardiovascular–kidney–metabolic syndrome: novel molecular mechanism and glucagon-like peptide-1-targeting therapy

ClinicalTrials.gov · Oct 23, 2026 · Phase 2 Trial

Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)

Gut Microbes · Oct 23, 2026 · Journal article

Gut virome remodeling after fecal microbiota transplantation is associated with virus–bacteria co-variation and metabolic response in obesity and type 2 diabetes

International Journal of Drug Delivery Technology · Oct 23, 2026 · Journal article

Prehabilitation and Early Recovery After Surgery (ERAS) in head and neck cancers: a protocol for a prospective, stratified, open-label randomised controlled trial in adults (PreERA)

Frontiers in Immunology · Oct 23, 2026 · Journal article

Advances in photothermal-driven tumor immunomodulation and synergistic therapy

Gynecologic Oncology Reports · Oct 23, 2026 · Journal article

Complete loss of all mismatch repair protein expression in endometrioid carcinoma: A first case report of null phenotype induced by MLH1 hypermethylation and MSH2 somatic mutation

Rapid Communications in Mass Spectrometry · Journal article

Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis.

International Journal of Methods in Psychiatric Research · Dec 1, 2026 · Journal article

Association Between Cerebrospinal Fluid Ghrelin Levels and Depressive Symptoms is Moderated by Smoking: A Case-Control Study.

Journal of Hepatology · Journal article

EASL-EASD-EASO Guidance for the Use of Resmetirom and Semaglutide as MASH-Targeted Therapy.

Genetic Epidemiology · Dec 1, 2026 · Journal article

Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome-Wide Association Studies.

The Lancet. Healthy Longevity · Journal article

Hearing loss, hearing-aid use, and mortality risk: individual participant data meta-analysis of population-based studies from Australia, Iceland, and the USA and a replication study from Norway.

The Lancet. Planetary Health · Journal article

Effects of a 3-day simulated heatwave on physiological and functional outcomes in older adults in Canada: a single-site randomised crossover trial.

Methods in Molecular Biology · Journal article

Concordance of Microbiological and Histopathological Examination of Bone Biopsies in Diagnosing Diabetic Foot Osteomyelitis, a Systematic Review.

Methods in Molecular Biology · Journal article

Immunophenotyping Studies in Nonhuman Primate Models.

The Lancet. Healthy Longevity · Journal article

Effectiveness of high-dose versus standard-dose influenza vaccines against hospitalisation according to frailty risk: a prespecified analysis of the randomised trial DANFLU-2.

Methods in Molecular Biology · Journal article

Trajectories of positive youth development, predictors, and mental health outcomes among Chinese adolescents: Examining group differences amid rural-to-urban migration.

Journal of Medical Primatology · Dec 1, 2026 · Journal article

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV-Important Lessons Learned.

Reviews of Physiology, Biochemistry and Pharmacology · Journal article

AA in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Nonalcoholic Fatty Liver Disease (NAFLD).

Methods in Molecular Biology · Journal article