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Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 23, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Phase 2 Trial.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT04637620). This is a study registration, not published results. Lead sponsor: China Medical University Hospital. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 90 participants (ESTIMATED). Conditions: Major Depressive Disorder. Interventions: DRUG: NMDAE; DRUG: Sertraline; DRUG: Placebo Cap. Primary outcome measures: Change in Hamilton Rating Scale for Depression , week 0, 2, 4, 6, 8; Change in Global Assessment of Functioning , Week 0, 2, 4, 6, 8. Brief summary: Most of the current antidepressants for major depressive disorder (MDD) are based upon the monoamine hypothesis which cannot fully explain the etiology of depression. NMDA hypofunction has been implicated in the pathophysiology of depression. Therefore, this study will examine the efficacy and safety as well as cognitive function improvement of an NMDA enhancer (NMDAE) in the treatment of MDD in the adults.