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Runzhi Chen

Hubei Provincial Center for Disease Control and Prevention

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SEP 8, 2026 · REVIEW

Clinical activity of chidamide-containing regimens after prior PD-1-based therapy in two patients with microsatellite-stable metastatic colorectal cancer: a case series and narrative review

Frontiers in Oncology

A two-patient retrospective case series with mixed responses (one PR, one SD) in a heavily pretreated population; descriptive observations that generate hypotheses rather than test them and are explicitly insufficient to demonstrate efficacy or resistance reversal.

Hypothesis-GeneratingColorectal Cancer Treatments and Studies Runzhi Chen Genetic Factors in Colorectal Cancer

Reported

Case 1 best responsepartial response

Case 1 PFS on chidamide plus sint…6 months

Case 1 PFS on prior regimen (suru…5 months

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