Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
A mechanistic study in cell lines showing how CHK2 deficiency alters DNA repair pathway engagement; findings are exploratory and require further investigation to establish clinical relevance.
Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale
A small, single-centre molecular profiling study from an underrepresented population reporting mutation frequencies and survival associations, without a comparator arm or randomization, that the authors themselves flag as requiring larger validation.
A two-patient retrospective case series with mixed responses (one PR, one SD) in a heavily pretreated population; descriptive observations that generate hypotheses rather than test them and are explicitly insufficient to demonstrate efficacy or resistance reversal.
This is a conceptual framework paper proposing mechanistic hypotheses about hepatic disease as a modifier of immunotherapy efficacy in colorectal cancer, without new primary data or definitive evidence.
Retrospective single-centre cohort with modest follow-up (1.4 years median) and no randomization; observational associations with biomarkers and treatment types are hypothesis-generating rather than definitive.
A well-designed preclinical study with mechanistic depth and human genetic support, but limited to mouse models and surrogate endpoints; findings require clinical validation.
Large prospective multicenter registry study with rigorous cross-sectional design and complete clinicopathological data, providing population-level prevalence estimates and validated independent predictors of mismatch repair deficiency in an unselected colorectal cancer cohort.
A single-center phase 2 trial with a meaningful primary endpoint (40% complete response) and acceptable safety, but limited by lack of control group, modest sample size, and single-center design requiring confirmation in larger studies.