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Yuehua Liang

Beijing Tsinghua Chang Gung Hospital

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SEP 7, 2026 · JOURNAL ARTICLE

Beyond mismatch repair in colorectal cancer liver metastases: rethinking immunotherapy through the hepatic metastatic niche

Frontiers in Immunology

This is a conceptual framework paper proposing mechanistic hypotheses about hepatic disease as a modifier of immunotherapy efficacy in colorectal cancer, without new primary data or definitive evidence.

Hypothesis-GeneratingYuehua Liang Wenqiang Wang Lei Yang

Reported

Sample size (Pakvisal retrospecti…132

Active liver metastases (Pakvisal)93

Clinical benefit with active live…16.1%

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