Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale
A small, single-centre molecular profiling study from an underrepresented population reporting mutation frequencies and survival associations, without a comparator arm or randomization, that the authors themselves flag as requiring larger validation.
A computational, exploratory bioinformatics study designed to generate hypotheses about lncRNA mechanisms in quercetin response, without experimental validation or causal evidence in breast cancer.
Well-designed single-center concordance study with clear methodology and strong statistical agreement (κ=0.98) that validates interchangeability of two antibodies in routine practice, but does not establish new clinical utility or change diagnostic approach.
Early-phase in vitro and xenograft study showing proof-of-concept for a three-drug combination in KRAS G12C NSCLC cells; mechanistic finding without human clinical data or toxicology beyond weight observation.
Early-stage natural product discovery using in vitro and mouse xenograft models with molecular docking; results are promising but preclinical and lack human data or regulatory validation.
This is a narrative review of mechanistic pathways and drug development concepts, not a clinical trial or meta-analysis, and raises questions about mTOR inhibitors rather than testing them in humans with measured outcomes.
This is a mechanistic discovery study using novel proteomics methodology to identify a protein interaction and propose a regulatory mechanism; it lacks clinical outcome data, patient treatment results, or even cell-based validation of therapeutic efficacy.
A mechanistically rigorous preclinical study demonstrating that menin inhibition reduces high-fat diet-induced weight gain in mice through intestinal lipid absorption limitation, supported by organoid validation but lacking human efficacy data.