Researcher

Zhihong Wang

Guiyang Medical University

2 developments in the corpus

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SEP 8, 2026 · JOURNAL ARTICLE

CNIH4 regulates systemic metabolism and exercise adaptations in male mice primarily through the modulation of β-adrenergic receptor trafficking

Nature Communications

Mechanistic study in male mice showing CNIH4 regulates β-adrenergic receptor trafficking and metabolic outcomes; lacks human data, clinical endpoints, or comparison to established interventions.

PreliminaryReceptor Mechanisms and Signaling Tao Bo Yong Zhang

Study details

DesignPreclinical mechanistic study using genetic…

InterventionGenetic deletion of CNIH4; pharmacological…

ComparatorWild-type or control mice; untreated knocko…

SEP 4, 2026 · JOURNAL ARTICLE

Benmelstobart plus antiangiogenic therapy vs chemotherapy for metastatic triple-negative breast cancer: phase III trial

npj Breast Cancer

Underpowered trial prematurely stopped at 46% of planned enrollment with non-significant primary endpoint; efficacy analyses explicitly stated as exploratory, requiring cautious interpretation.

PreliminaryYu Ren Binghe Xu Zhihong Wang

Reported

Sample size147

Planned enrollment322

Median PFS (combination, investig…7.85 months