SEP 8, 2026 · JOURNAL ARTICLE
CNIH4 regulates systemic metabolism and exercise adaptations in male mice primarily through the modulation of β-adrenergic receptor trafficking
Nature Communications
Mechanistic study in male mice showing CNIH4 regulates β-adrenergic receptor trafficking and metabolic outcomes; lacks human data, clinical endpoints, or comparison to established interventions.
Study details
DesignPreclinical mechanistic study using genetic…
InterventionGenetic deletion of CNIH4; pharmacological…
ComparatorWild-type or control mice; untreated knocko…