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Yan Liu

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SEP 7, 2026 · JOURNAL ARTICLE

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Journal of Gastroenterology

Mechanistic study in syngeneic and humanized mouse models demonstrating a novel immunological pathway; lacks efficacy data from human trials and is not powered to establish clinical benefit.

PreliminaryBeibei Ran Yan Liu Chunping Jiang

Study details

DesignPreclinical and humanized mouse model study

InterventionADV-PRK: oncolytic adenovirus engineered to…

ComparatorNot explicitly stated; control appears to b…

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