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A modelling study demonstrating that 3D volumetric imaging outperforms RECIST 1.1 for capturing tumor dynamics in silico; raises a hypothesis about measurement methods rather than testing it clinically.
This is a narrative review synthesizing evidence across multiple preoperative colorectal cancer strategies, providing decision boundaries and clinical recommendations rather than reporting original trial data.
A conceptual review proposing an integrative framework for ctDNA and immune biomarkers in MRD surveillance, without new primary data or prospective validation of the proposed model.
Large, rigorous meta-analysis of 38 randomized phase 3 trials with 31,721 patients showing statistically significant OS and disease-free survival benefits from ICIs in curative solid tumors, with no sex difference detected, though female underrepresentation limits generalizability.
Systematic review of economic evidence synthesizing 18 model-based evaluations to inform policy on NGS adoption in NSCLC, with contextual conclusions about cost-effectiveness variability rather than a single definitive clinical or economic finding.
A prospective case–control study of modest size (150 participants) with clear separation between groups and strong ROC performance for a candidate biomarker, but surrogate endpoints (AUC, survival association) rather than a clinical trial of intervention, requiring confirmation in independent cohorts.
A structured narrative review synthesizing evidence from 99 foundational studies and clinical documents to provide organized guidance on molecular biomarkers, diagnostic methods, and resistance mechanisms in NSCLC precision oncology, rather than reporting original trial data.
Retrospective real-world database analysis of testing utilization and costs across nine cancer types; descriptive findings on patterns and cost variation, but without comparative efficacy, clinical outcome, or causal inference.