Gastrointestinal Tumor Research and Treatment

SEP 7, 2026 · JOURNAL ARTICLE

Clinical translation of CLDN18.2 and FGFR2b targeting in gastric cancer through assay thresholds and combination strategies

Discover Oncology

A narrative review synthesizing evidence across randomized trials and translational studies to distinguish established clinical practice from exploratory strategies in gastric cancer biomarker-directed therapy.

SEP 7, 2026 · JOURNAL ARTICLE

Surgical management of small bowel metastasis from esophageal squamous cell carcinoma: a case report and literature review

Frontiers in Surgery

A single case report with clinical narrative describing an unusual metastatic pattern; it raises mechanistic hypotheses and clinical management questions but provides no comparative data, control group, or generalizable evidence.

SEP 5, 2026 · JOURNAL ARTICLE

Comparative efficacy and safety of neoadjuvant and perioperative systemic therapies for resectable locally advanced gastric and gastroesophageal junction adenocarcinoma: a network meta analysis of randomized controlled trials

BMC Gastroenterology

Network meta-analysis of 36 RCTs with 8925 patients comparing defined treatment classes for resectable locally advanced gastric cancer, with consistent superiority of chemotherapy plus immunotherapy across survival and pathological endpoints, but limited by indirect comparisons and heterogeneous trial populations.

SEP 4, 2026 · JOURNAL ARTICLE

Clinical outcomes of SMARCA4-deficient thoracic tumor patients and therapeutic value of immune checkpoint inhibitors in advanced stage patients

BMC Cancer

Single-centre retrospective cohort with small advanced-stage subgroups (n=16 per arm) and exploratory analyses; unadjusted PFS benefit for ICIs did not survive adjustment, and authors explicitly state findings are hypothesis-generating rather than confirmatory.

SEP 4, 2026 · JOURNAL ARTICLE

Heterogeneity-oriented multidisciplinary and super-minimally invasive precision treatment framework for locally advanced gastric cancer

World Journal of Translational Medicine

This is a conceptual framework paper proposing a treatment approach for locally advanced gastric cancer, explicitly lacking primary clinical data and validation, presented as a hypothesis-driven concept requiring future prospective testing.

AUG 17, 2026 · REVIEW

Efficacy hierarchy and absolute survival benefit of first-line immunotherapy in advanced gastric cancer: a meta-analysis and pooled survival analysis

Frontiers in Immunology

High-quality meta-analysis of 8 phase III RCTs with 7,127 patients showing consistent, statistically significant OS and PFS benefit for ICI-chemotherapy over chemotherapy alone in advanced gastric cancer, with clinically meaningful absolute survival gains and manageable toxicity.

AUG 17, 2026 · JOURNAL ARTICLE

Multidimensional decision support by artificial intelligence across the full workflow of endoscopic submucosal dissection for early gastric cancer

Frontiers in Oncology

A systematic review examining the state of AI application across the ESD workflow for early gastric cancer, synthesizing progress, limitations, and future directions to inform clinical translation rather than reporting original clinical trial data.

AUG 16, 2026 · JOURNAL ARTICLE

Optimal Management of Clinical T2N0 Gastric Adenocarcinoma: Surgery or Chemotherapy First?

Journal of Surgical Oncology

Large, well-powered observational cohort study from a national database demonstrating superior survival with adjuvant versus perioperative chemotherapy in cT2N0 gastric cancer, with multivariable analysis and clear effect sizes, though observational design limits causal inference.