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A narrative review synthesizing case reports and empirical estimates of a rare condition with acknowledged lack of large-scale epidemiological data, offering descriptive and mechanistic insight but no original empirical evidence or comparative outcomes.
Single-centre retrospective case series of 8 patients describing clinicopathological features and immune markers after sarcomatoid transformation; no control group, no comparative analysis, and no clinical outcomes reported.
Single case report of rare breast cancer histology treated with multidisciplinary therapy; describes clinical course and treatment response but provides no comparative data, control arm, or generalizable evidence.
A single case report integrated with bibliometric review and exploratory bioinformatic analysis of gene expression datasets; no clinical trial, no new diagnostic or therapeutic validation, and no quantitative evidence of intervention efficacy beyond one patient's response.
A single case report with clinical narrative describing an unusual metastatic pattern; it raises mechanistic hypotheses and clinical management questions but provides no comparative data, control group, or generalizable evidence.
Single-centre retrospective cohort with small advanced-stage subgroups (n=16 per arm) and exploratory analyses; unadjusted PFS benefit for ICIs did not survive adjustment, and authors explicitly state findings are hypothesis-generating rather than confirmatory.
A single clinical case report describing an unusual diagnostic presentation; raises awareness of a rare mimicry but provides no generalizable evidence about incidence, diagnosis, or management.
Small single-center retrospective cohort (n=22) with univariate analysis only, addressing a rare disease with no established standard, yielding a promising survival signal but explicitly requiring large prospective validation.