Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
A single case report of an uncommon clinical scenario with no control group, comparative data, or systematic evidence; describes feasibility and tolerability in one patient but cannot establish efficacy or guide clinical practice.
A novel biomarker derived from retrospective cohort data with validation in two independent datasets, showing consistent association with overall survival in pancreatic cancer, but lacking mechanistic validation or clinical intervention trials to establish actionability.
In vitro mechanistic study in immortalized keratinocytes using CRISPR knockouts, demonstrating pathway defects and proof-of-concept rescue; lacks in vivo validation or clinical outcome data required for stronger evidence.