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Elizabeth J. Olecki

University of Missouri–Kansas City

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AUG 16, 2026 · JOURNAL ARTICLE

Optimal Management of Clinical T2N0 Gastric Adenocarcinoma: Surgery or Chemotherapy First?

Journal of Surgical Oncology

Large, well-powered observational cohort study from a national database demonstrating superior survival with adjuvant versus perioperative chemotherapy in cT2N0 gastric cancer, with multivariable analysis and clear effect sizes, though observational design limits causal inference.

Strong EvidenceMatthew Dixon Elizabeth J. Olecki Esophageal Cancer Research and Treatment

Reported

Sample size (total)3676

Sample size (upfront surgery)2961

Hazard ratio (perioperative chemo…0.64

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