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Sabine Denize

International Charter School

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AUG 17, 2026 · REVIEW

Efficacy hierarchy and absolute survival benefit of first-line immunotherapy in advanced gastric cancer: a meta-analysis and pooled survival analysis

Frontiers in Immunology

High-quality meta-analysis of 8 phase III RCTs with 7,127 patients showing consistent, statistically significant OS and PFS benefit for ICI-chemotherapy over chemotherapy alone in advanced gastric cancer, with clinically meaningful absolute survival gains and manageable toxicity.

Strong EvidenceJialun Lv Sabine Denize Krishnapriya Thangaretnam

Reported

Sample size7127

Number of trials8

Overall survival hazard ratio0.79

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