Cancer Cells and Metastasis

SEP 10, 2026 · JOURNAL ARTICLE

Beyond Conventional PDOs: Organoids for Tumorigenesis for Gut Cancer Modeling and Fast Clinical Decision

Gut Medicine

A perspective review raising questions about organoid models for cancer rather than reporting empirical results, mechanistic findings, or clinical outcomes with measured effect sizes.

SEP 9, 2026 · JOURNAL ARTICLE

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science

Preclinical discovery and optimization study with in vitro, xenograft, and animal toxicology data, but no human clinical evidence; Phase 1 trial is only stated as 'underway' with no results reported.

SEP 9, 2026 · JOURNAL ARTICLE

UQCRC2 lactylation-mediated mitophagy orchestrates colorectal cancer cell metabolism to establish a drug-tolerant state during chemotherapy

Molecular Cancer

Mechanistic study in cell and animal models identifying a pathway linking lactylation to drug tolerance, with clinical associations but no prospective clinical trial or intervention outcome data.

SEP 9, 2026 · JOURNAL ARTICLE

Reprogramming the immune landscape in lung cancer: spatial and metabolic contexts of c-MET signaling

Journal of Translational Medicine

This is a narrative review raising mechanistic questions about MET signaling in lung cancer immunology rather than reporting empirical results from original research.

SEP 9, 2026 · JOURNAL ARTICLE

A SORT1-associated transcriptional signature links adipogenic plasticity, stemness and drug-resistance programs in 3D glioblastoma spheroids: dissection of ligand-dependent and ligand-independent arms

BMC Cancer

This is an exploratory mechanistic study in cultured glioblastoma cells using gene expression arrays and pharmacological perturbations to propose a model of SORT1 function; the authors explicitly state the model 'remains to be tested with direct functional assays', and no clinical outcome or animal validation is presented.

SEP 9, 2026 · JOURNAL ARTICLE

Commensal Nakaseomyces glabratus migrates into prostate tumors to accelerate cancer progression

Nature Cancer

Mechanistic discovery in animal models with correlative human data; no clinical trial evidence, no intervention tested in patients, and no hard clinical outcomes reported.

SEP 8, 2026 · JOURNAL ARTICLE

Beyond CA-125: circulating cell-free DNA as the next-generation biomarker in ovarian malignancy

BMC Cancer

A prospective case–control study of modest size (150 participants) with clear separation between groups and strong ROC performance for a candidate biomarker, but surrogate endpoints (AUC, survival association) rather than a clinical trial of intervention, requiring confirmation in independent cohorts.

SEP 8, 2026 · JOURNAL ARTICLE

CAF-mediated immune exclusion in osteosarcoma: mechanisms, translational vulnerabilities, and therapeutic strategies

Journal of Translational Medicine

This is a narrative review synthesizing mechanistic and preclinical evidence on CAF biology in osteosarcoma, proposing translational directions without clinical trial data or validated biomarkers.