Cancer, Stress, Anesthesia, and Immune Response

SEP 8, 2026 · JOURNAL ARTICLE

Time to benefit of perioperative immunotherapy among patients with resectable non-small-cell lung cancer

BMC Cancer

Rigorous meta-analysis of 8 RCTs with reconstructed individual patient data and quantitative time-to-benefit modelling provides robust evidence on treatment duration, though findings are primarily analytical rather than from a new primary trial.

SEP 8, 2026 · JOURNAL ARTICLE

Vortioxetine enhances the anti-pancreatic cancer efficacy of gemcitabine through reducing MAOB expression

Frontiers in Pharmacology

Preclinical in vitro and xenograft study proposing a mechanism by which an existing drug may enhance chemotherapy, without clinical efficacy data or human evidence.

SEP 8, 2026 · JOURNAL ARTICLE

Emerging Roles of TMEM97/Sigma-2 Receptor in Breast Cancer Endocrine Resistance: Links to mTOR Signaling and Cholesterol Metabolism

Kinases and Phosphatases

This is a mechanistic review summarizing preclinical evidence linking TMEM97/sigma-2 receptor to endocrine resistance pathways; the source explicitly states evidence remains preclinical and further investigation is needed.

SEP 7, 2026 · REVIEW

A narrative review on immune checkpoint inhibitor drug interactions with statins, proton pump inhibitors and corticosteroids

Discover Medicine

A narrative review synthesizing observational and meta-analytic evidence on drug–ICI interactions, offering clinical recommendations on statin, PPI, and corticosteroid use during checkpoint inhibitor therapy, but not reporting new primary data.

SEP 7, 2026 · JOURNAL ARTICLE

Long-term exposure of Lactobacillus rhamnosus to quercetin enhances its anti-angiogenic and anti-colorectal cancer efficacy

Scientific Reports

In vitro mechanistic study demonstrating enhanced probiotic metabolite activity against colorectal cancer cells and angiogenesis, but lacking in vivo efficacy data, clinical endpoints, or human translation.

SEP 7, 2026 · JOURNAL ARTICLE

Adjuvant therapy and fear of cancer recurrence in bladder cancer survivors: a cross-sectional pilot study

BMC Urology

A single-centre, underpowered cross-sectional pilot study explicitly designed as hypothesis-generating, with a null primary finding that the authors acknowledge cannot rule out a clinically meaningful effect.

SEP 6, 2026 · JOURNAL ARTICLE

Perineural invasion in hepatocellular carcinoma: clinical evidence and mechanistic hypotheses

Journal of Translational Medicine

A synthesis paper proposing mechanistic hypotheses for perineural invasion in HCC based on limited and inconsistently defined clinical data, without new experimental results or clinical trials to test the proposed mechanisms.

SEP 4, 2026 · JOURNAL ARTICLE

Hypersensitivity Reactions to Anticancer Drugs: A Prospective Study at Azadi Hematology Oncology Center, Duhok

Advanced Medical Journal

Single-centre prospective observational study over 9 weeks with small absolute number of events (n=7) reporting incidence rate; descriptive rather than comparative, and lacks control or mechanistic depth to support generalization.