Virus-based Gene Therapy Research

SEP 8, 2026 · JOURNAL ARTICLE

mRNA therapeutics in cancer: from molecular design to clinical translation

Molecular Cancer

A comprehensive review synthesizing the state of mRNA cancer therapeutics across design, delivery, and clinical translation—expert framing rather than a new empirical finding.

SEP 8, 2026 · JOURNAL ARTICLE

Nanocarrier-Mediated Gene Editing for Improved Tumour Therapeutic Efficacy

Theoretical and Natural Science

A narrative review of preclinical literature synthesizing nanocarrier design and CRISPR delivery mechanisms, raising research directions rather than reporting original empirical evidence or clinical outcomes.

SEP 7, 2026 · JOURNAL ARTICLE

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Journal of Gastroenterology

Mechanistic study in syngeneic and humanized mouse models demonstrating a novel immunological pathway; lacks efficacy data from human trials and is not powered to establish clinical benefit.

SEP 6, 2026 · JOURNAL ARTICLE

Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases

Stem Cell Research & Therapy

A narrative review synthesizing advances in CAR-T engineering strategies for multiple disease contexts, offering conceptual direction rather than new empirical evidence or clinical outcomes.

SEP 4, 2026 · JOURNAL ARTICLE

Oncofetal antigens as emerging targets in chimeric antigen receptor (CAR)-T cell-based immunotherapies: opportunities and challenges

Frontiers in Cell and Developmental Biology

A narrative mini-review synthesizing biological rationale, clinical trial experience, and emerging strategies for oncofetal antigen-targeted CAR-T therapies, offering expert perspective on opportunities and limitations rather than novel empirical findings.

AUG 30, 2026 · JOURNAL ARTICLE

CRISPR/Cas9 technology in oncology: mechanisms, applications, and future perspectives

Сибирский Научный Медицинский Журнал

A narrative review article that synthesizes mechanistic understanding and preclinical applications of CRISPR/Cas9 in oncology without reporting primary empirical findings, efficacy data, or clinical outcomes.

AUG 28, 2026 · JOURNAL ARTICLE

Unraveling Hemophilia in the Modern Era: From Pathogenesis to Emerging Therapies

Current Advances in Medicine.

A comprehensive narrative review synthesizing epidemiology, pathophysiology, diagnostics, and therapeutic approaches to hemophilia without presenting new primary data or meta-analytic synthesis.

AUG 27, 2026 · JOURNAL ARTICLE

Applications and Future Perspectives of CRISPR/Cas9 Gene Editing Technologies in CAR-T Cell Therapy

International Journal of Biology and Life Sciences

This is a narrative review discussing potential applications of CRISPR/Cas9 in CAR-T engineering without presenting new empirical data, clinical trials, or quantified evidence to support the proposed approaches.