CAR-T Cell Therapy Research

SEP 10, 2026 · JOURNAL ARTICLE

Cancer-driver-agnostic targeting of amplified surface proteins identifies MPZL1 for selective CAR-T cell therapy

Nature Communications

This is preclinical target discovery and validation work using in vitro and animal models; it establishes MPZL1 as a candidate CAR-T target but does not present clinical efficacy data or human trials.

SEP 10, 2026 · JOURNAL ARTICLE

Cancer-Specific Exons as Pan-Tumor CAR-T Targets in Pediatric Solid and Brain Tumor

Indian Journal of Medical and Paediatric Oncology

A conceptual and critical synthesis of an emerging biological strategy without original experimental data, clinical trials, or validated clinical outcomes in the source population.

SEP 10, 2026 · JOURNAL ARTICLE

Harnessing tumor immune checkpoints for autoimmune disease therapeutics

Frontiers in Immunology

This is a narrative review synthesizing mechanistic concepts and early clinical observations rather than reporting original experimental or clinical trial data with defined endpoints and effect sizes.

SEP 8, 2026 · JOURNAL ARTICLE

Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer

Frontiers in Immunology

A comprehensive review summarizing molecular principles, clinical progress, and translational strategies for targeted protein degradation in cancer immunotherapy, rather than reporting original experimental data or trial results.

SEP 8, 2026 · JOURNAL ARTICLE

Blinatumomab Care Delivery for Pediatric B-Cell Acute Lymphoblastic Leukemia

JAMA Network Open

A cross-sectional survey of clinical practice and implementation challenges with no quantitative comparison group, efficacy data, or primary outcome measure; descriptive in nature and identifying barriers rather than testing an intervention or confirming an effect.

SEP 8, 2026 · JOURNAL ARTICLE

Re-expression of MHC-I to treat CNS cancers

Oncotarget

This is a mechanistic review discussing potential strategies to restore MHC-I in CNS cancers, raising questions about therapeutic approaches rather than presenting experimental results or clinical evidence.

SEP 7, 2026 · JOURNAL ARTICLE

Beyond approval: a mechanism-based review of novel anti-tumour agents in cervical cancer and when to use them

Frontiers in Immunology

A narrative mechanism-based review synthesizing evidence across drug classes to guide clinical decision-making in cervical cancer treatment, without presenting original trial data or meta-analytic synthesis.

SEP 7, 2026 · JOURNAL ARTICLE

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Journal of Gastroenterology

Mechanistic study in syngeneic and humanized mouse models demonstrating a novel immunological pathway; lacks efficacy data from human trials and is not powered to establish clinical benefit.