CAR-T Cell Therapy Research

SEP 8, 2026 · JOURNAL ARTICLE

Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer

Frontiers in Immunology

A comprehensive review summarizing molecular principles, clinical progress, and translational strategies for targeted protein degradation in cancer immunotherapy, rather than reporting original experimental data or trial results.

SEP 8, 2026 · JOURNAL ARTICLE

Blinatumomab Care Delivery for Pediatric B-Cell Acute Lymphoblastic Leukemia

JAMA Network Open

A cross-sectional survey of clinical practice and implementation challenges with no quantitative comparison group, efficacy data, or primary outcome measure; descriptive in nature and identifying barriers rather than testing an intervention or confirming an effect.

SEP 8, 2026 · JOURNAL ARTICLE

Re-expression of MHC-I to treat CNS cancers

Oncotarget

This is a mechanistic review discussing potential strategies to restore MHC-I in CNS cancers, raising questions about therapeutic approaches rather than presenting experimental results or clinical evidence.

SEP 7, 2026 · JOURNAL ARTICLE

Beyond approval: a mechanism-based review of novel anti-tumour agents in cervical cancer and when to use them

Frontiers in Immunology

A narrative mechanism-based review synthesizing evidence across drug classes to guide clinical decision-making in cervical cancer treatment, without presenting original trial data or meta-analytic synthesis.

SEP 7, 2026 · JOURNAL ARTICLE

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Journal of Gastroenterology

Mechanistic study in syngeneic and humanized mouse models demonstrating a novel immunological pathway; lacks efficacy data from human trials and is not powered to establish clinical benefit.

SEP 7, 2026 · JOURNAL ARTICLE

Tissue-localized immunoengineering for in situ reprogramming of immune cells in cancer therapy

Discover Oncology

This is a narrative review proposing an emerging paradigm of tissue-localized immunoengineering; it raises conceptual and mechanistic questions rather than reporting original empirical evidence or clinical outcomes.

SEP 6, 2026 · JOURNAL ARTICLE

Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases

Stem Cell Research & Therapy

A narrative review synthesizing advances in CAR-T engineering strategies for multiple disease contexts, offering conceptual direction rather than new empirical evidence or clinical outcomes.

SEP 4, 2026 · JOURNAL ARTICLE

Oncofetal antigens as emerging targets in chimeric antigen receptor (CAR)-T cell-based immunotherapies: opportunities and challenges

Frontiers in Cell and Developmental Biology

A narrative mini-review synthesizing biological rationale, clinical trial experience, and emerging strategies for oncofetal antigen-targeted CAR-T therapies, offering expert perspective on opportunities and limitations rather than novel empirical findings.