Immunotherapy and Immune Responses

SEP 8, 2026 · JOURNAL ARTICLE

Transmembrane lectins in cancer immunity: emerging drivers of myeloid-mediated immunosuppression

Frontiers in Immunology

A narrative review synthesizing mechanistic concepts and therapeutic potential of lectin–glycan interactions in cancer immunity, raising questions rather than reporting empirical results or clinical outcomes.

SEP 8, 2026 · JOURNAL ARTICLE

Re-expression of MHC-I to treat CNS cancers

Oncotarget

This is a mechanistic review discussing potential strategies to restore MHC-I in CNS cancers, raising questions about therapeutic approaches rather than presenting experimental results or clinical evidence.

SEP 7, 2026 · JOURNAL ARTICLE

Beyond approval: a mechanism-based review of novel anti-tumour agents in cervical cancer and when to use them

Frontiers in Immunology

A narrative mechanism-based review synthesizing evidence across drug classes to guide clinical decision-making in cervical cancer treatment, without presenting original trial data or meta-analytic synthesis.

SEP 7, 2026 · JOURNAL ARTICLE

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Journal of Gastroenterology

Mechanistic study in syngeneic and humanized mouse models demonstrating a novel immunological pathway; lacks efficacy data from human trials and is not powered to establish clinical benefit.

SEP 7, 2026 · JOURNAL ARTICLE

IL-10’s contextual role in cytotoxic antitumor immunity: evidence, controversies, and therapeutic translation

Frontiers in Immunology

This is a narrative review synthesizing mechanistic evidence and preclinical models with conflicting human data, proposing a framework rather than reporting a new empirical result; the only completed Phase 3 trial (pegilodecakin) failed its primary endpoint.

SEP 6, 2026 · JOURNAL ARTICLE

Characterization of the immune status in the tumor microenvironment of solid cancers with chromosomal instability

Cancer Immunology Immunotherapy

Single-centre observational study applying a previously developed algorithm to correlative genomic and immune data without experimental validation, prospective clinical outcome assessment, or comparison to an independent cohort.

SEP 5, 2026 · JOURNAL ARTICLE

RAD001-Adjuvanted Influenza Vaccine Synergizes With Anti–Programmed Cell Death Protein 1 Therapy to Enhance Antitumor Immunity in Programmed Cell Death Ligand 1–Low Murine Lung Cancer

World Journal of Oncology

A mechanistic preclinical study in a murine model showing synergistic efficacy of a novel vaccine-adjuvant combination with PD-1 blockade, with supporting immunological data but requiring clinical translation.

SEP 5, 2026 · JOURNAL ARTICLE

Cancer vaccines as targeted therapies: translational advances and challenges

Immunotherapy

This is a narrative review that raises questions and summarizes progress rather than reporting empirical results with effect sizes or comparative outcomes to answer them.