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Yi Wu

Harbin Medical University

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JUL 29, 2026 · JOURNAL ARTICLE

Enhancer-mediated DDIT4 activation by SMYD2-dependent H3K4me1 promotes pazopanib resistance in clear cell renal cell carcinoma

Journal of Translational Medicine

This is a mechanistic study identifying a regulatory axis through molecular and cellular assays with supporting murine models, but lacks a prospective clinical trial design, hard clinical endpoints, or validation in independent patient cohorts.

Hypothesis-GeneratingMengyao Wang Beichen Ding Yi Wu

Reported

Patient sample size150

DDIT4 distal enhancer locationchr10:72830412–72830891

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