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Retrospective single-centre assessment of theoretical eligibility and drug-drug interactions; descriptive analysis without a comparator, control group, or clinical outcome measurement.
Prospective cohort study with adequate sample size and hard clinical outcomes (CVD, cancer, death), but unadjusted effect is attenuated to borderline significance after adjustment (aHR 1.28, 95% CI 0.98–1.67, p=0.073), limiting definitive causal inference.