Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
Integrated multi-omics analysis in a large single-centre TNBC cohort with mechanistic mouse experiments and supportive clinical trial data, but observational design, no randomized comparator, and reliance on retrospective trial analysis limit definitive claims about causation or clinical practice change.
Cross-sectional survey of nutritional status in cancer patients using validated screening tools; descriptive prevalence findings without a comparator group, control arm, or analytical testing of interventions.
Retrospective cohort study of 330 patients reporting an obesity paradox in mHSPC; confirms known associations but BMI did not retain independent significance in multivariate analysis, limiting practice implications.
A large, well-designed retrospective cohort study with robust methods (inverse-probability weighting, competing-risks analysis) that confirms the absence of a clinically meaningful difference in circulatory mortality between treatment sequences, with narrow confidence intervals crossing the null.
A narrative review synthesizing evidence on metabolic interventions for endometrial cancer in obesity, offering clinical recommendations but explicitly acknowledging gaps in prospective evidence for oncologic outcomes.
Prospective cohort study with adequate sample size and hard clinical outcomes (CVD, cancer, death), but unadjusted effect is attenuated to borderline significance after adjustment (aHR 1.28, 95% CI 0.98–1.67, p=0.073), limiting definitive causal inference.
Single-centre cross-sectional descriptive study of hormone receptor prevalence in a resource-limited setting; establishes local epidemiology but lacks comparison group, prospective outcome data, or causal inference.
A perspective article proposing mechanistic relationships between insulin resistance, DPP4, and mitochondrial dysfunction in cancer, without presenting primary empirical data or clinical trials to test the hypothesis.