Genetic and Kidney Cyst Diseases

SEP 7, 2026 · JOURNAL ARTICLE

Aerobic Exercise Ameliorates Renal Injury in High‐Fat Diet‐Fed Mice: A Novel Effect Mediated by the Drp1‐mtROS Pathway

Acta Physiologica

A mechanistic study in mice and cultured cells demonstrating aerobic exercise reduces renal injury via Drp1-mtROS inhibition; the pathway is novel and supported by consistent findings across models, but lacks direct clinical validation and hard renal outcomes.

AUG 24, 2026 · REVIEW

Recent advances in therapeutic signaling pathways in polycystic kidney disease: insights from contemporary translational disease models- a narrative review

BMC Nephrology

This is a narrative review synthesizing experimental and translational findings across multiple model systems; it raises mechanistic questions and identifies therapeutic targets rather than reporting clinical trial results or definitive evidence from human studies.

AUG 24, 2026 · JOURNAL ARTICLE

Clinical validation of KIF11 overexpression in colorectal cancer and its potential association with the antitumor effects of nitidine chloride

Hereditas

This is a mechanistic discovery study combining computational prediction, molecular profiling, and cell-based experiments that propose KIF11 as a target and NC as a candidate agent, but lacks clinical efficacy data, adequate in vivo validation, or direct evidence of NC's antitumor effect in animal models.

AUG 14, 2026 · JOURNAL ARTICLE

Precision Medicine in patients with rare forms of genetic obesity: Necessity for coordinated and structured care

The Journal of Clinical Endocrinology & Metabolism

European expert consensus recommendation for structured care and centres of expertise in rare monogenic obesity, addressing diagnosis, access, and monitoring for newly approved MC4R agonist therapies.

AUG 11, 2026 · JOURNAL ARTICLE

Optimal timing of recombinant growth hormone therapy in Prader-Willi syndrome: the case for very early initiation

Frontiers in Endocrinology

This is a narrative commentary synthesizing existing evidence to recommend early rhGH initiation in PWS, not reporting new primary data or a systematic review with meta-analysis.

JUL 18, 2026 · JOURNAL ARTICLE

EMERGING GENE EDITING APPROACHES FOR CFTR CORRECTION IN CYSTIC FIBROSIS

Scientific Records

A narrative review of emerging gene editing technologies with preclinical evidence only; no clinical trial data, efficacy figures, or comparative results are reported.