Retinal Development and Disorders

SEP 3, 2026 · JOURNAL ARTICLE

Artificial intelligence-guided engineering of precision ocular therapeutics

Current Opinion in Ophthalmology

This is a narrative review surveying AI-guided drug discovery approaches in ophthalmology with mostly preclinical findings; it raises questions about translational potential rather than reporting clinical evidence or definitive efficacy.

SEP 1, 2026 · JOURNAL ARTICLE

Kcnv2 E151X Mouse Captures Hallmarks of KCNV2 ‐Associated Retinal Dystrophy

Clinical and Experimental Ophthalmology

This is a proof-of-concept animal model study establishing that a mutant mouse line recapitulates disease hallmarks; it is descriptive and preclinical, designed to enable future mechanistic and therapeutic work rather than to test an intervention.

AUG 27, 2026 · JOURNAL ARTICLE

CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage

Stem Cell Reports

This is a proof-of-concept study using CRISPR-based gene activation to direct iPSC differentiation toward notochordal cells, with single-cell sequencing validation but no functional in vivo data, clinical outcomes, or comparison to standard differentiation methods.

AUG 19, 2026 · JOURNAL ARTICLE

CRISPR-Cas9 and the Future of Ocular Retinal Therapy: A New Era for Ocular Disease

Current Advances in Medicine.

This is a narrative review synthesizing preclinical and early-stage trial evidence without new primary data, raising mechanistic potential rather than demonstrating clinical efficacy in humans.

AUG 11, 2026 · JOURNAL ARTICLE

Delineation of the molecular spectrum of ocular genetic disorders in the United Arab Emirates

Human Genomics

A retrospective cohort study describing genetic variants in ocular disorders without a comparator group, control arm, or quantified clinical outcomes; provides epidemiologic and descriptive data but lacks the design to support causal inference or clinical decision-making.

AUG 7, 2026 · JOURNAL ARTICLE

Intracellular Retinoid-Binding Proteins (CRBP, CRALBP, CRABP) as Emerging Drug Targets in Retinal Disease

International Journal of Molecular Sciences

This is a narrative review article evaluating druggability of retinoid-binding proteins based on structural and biochemical evidence, raising questions about therapeutic potential rather than reporting clinical trial results or definitive efficacy data.

JUL 31, 2026 · JOURNAL ARTICLE

Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus

Fluids and Barriers of the Cns

Early-stage preclinical work demonstrating proof-of-concept for a novel AAV capsid in tissue culture and small animal models, with identified technical barriers to clinical translation.

JUL 30, 2026 · JOURNAL ARTICLE

Emerging Technologies for Vision Restoration: Clinical Advances in Retinal Prostheses, Gene Therapy, Neuroprosthetics and Regenerative Ophthalmology

Ieccmexico

A narrative review synthesizing international evidence across multiple emerging technologies for vision restoration, offering expert interpretation of the current landscape rather than reporting original research data.