AUG 27, 2026 · JOURNAL ARTICLE
CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage
Stem Cell Reports
This is a proof-of-concept study using CRISPR-based gene activation to direct iPSC differentiation toward notochordal cells, with single-cell sequencing validation but no functional in vivo data, clinical outcomes, or comparison to standard differentiation methods.
Study details
DesignExploratory in vitro study with CRISPR-base…
InterventionCRISPR-based transactivation (CRISPRa) of n…