Importance Trastuzumab rezetecan (SHR-A1811) has demonstrated encouraging antitumor activity in a global phase 1 trial involving heavily pretreated patients with erythroblastic onc
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Importance Trastuzumab rezetecan (SHR-A1811) has demonstrated encouraging antitumor activity in a global phase 1 trial involving heavily pretreated patients with erythroblastic onc
Importance Obesity affects 15% of children aged 2 to 5 years and 22% of children aged 6 to 11 years in the US. Obesity in children is associated with dyslipidemia, hypertension, me
SEP 30, 2026 · JOURNAL ARTICLE
JAMA
Importance Although metabolic dysfunction–associated steatotic liver disease (MASLD) is traditionally associated with obesity, it is increasingly recognized in individuals with nor
Importance Advances in tumor immunology and vaccine technology are reshaping cancer vaccine development after decades of limited clinical success. More than 2000 immunogenic tumor
AUG 13, 2026 · JOURNAL ARTICLE
JAMA
Phase 3 randomized controlled trial with adequate sample size and median 3.2-year follow-up showing SBRT improved bowel quality of life and reduced high-grade genitourinary toxicity, but had lower disease-free survival than MH-IMRT.
Retrospective registry analysis describing focal therapy adoption patterns and characterizing use across risk groups, but providing no efficacy or safety outcomes to support clinical decision-making.
AUG 10, 2026 · JOURNAL ARTICLE
JAMA
Phase 3 RCT with adequately powered, pre-specified primary endpoint showing clinically significant and statistically robust PFS benefit (HR 0.44, p<.001) in a well-defined population, though OS remains immature and generalizability is limited to China.
A rigorous meta-analysis of 1725 patients demonstrates that ctDNA levels are strongly associated with disease-free and overall survival across multiple cancer settings, with consistent hazard ratios and statistical significance, though optimal clinical application remains incompletely defined.