A rigorous meta-analysis of 1725 patients demonstrates that ctDNA levels are strongly associated with disease-free and overall survival across multiple cancer settings, with consistent hazard ratios and statistical significance, though optimal clinical application remains incompletely defined.
Reported
Sample size (meta-analysis)1725
Hazard ratio for disease-free sur…20.69
95% CI for HR disease-free surviv…9.63–44.43