The International Journal of Neuropsychopharmacology
Large, well-designed cross-sectional neuroimaging and genetic study with unsupervised clustering that identifies distinct MDD subtypes and their cardiometabolic risk profiles, but lacks prospective validation, longitudinal follow-up, and independent replication needed to confirm clinical utility.
The International Journal of Neuropsychopharmacology
A sound cross-sectional study with pre-specified biomarker hypotheses and ROC analysis showing female-specific IL-6 and CRP associations with MDD in obesity, but limited by small sample size, single setting, and lack of longitudinal or independent validation.
The International Journal of Neuropsychopharmacology
This is a narrative evidence synthesis proposing mechanistic links between metabolic dysfunction and suicidality, and raising testable hypotheses about GLP-1RA effects on psychiatric outcomes; it does not report original trial results or definitive causal evidence, but rather integrates existing literature to frame future research directions.
The International Journal of Neuropsychopharmacology
In vitro mechanistic study in healthy donor cells using a viral mimetic; demonstrates psilocin's immunomodulatory effects on gene expression but lacks clinical outcome data, disease-relevant populations, or validation in vivo.
The International Journal of Neuropsychopharmacology
This is a prospective project description outlining aims and expected results, not a completed study with empirical findings; it raises mechanistic and clinical hypotheses about pro-resolving mediators in depression but presents no data to evaluate.