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B Vai

IRCCS Ospedale San Raffaele

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SEP 1, 2026 · JOURNAL ARTICLE

602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank

The International Journal of Neuropsychopharmacology

Large, well-designed cross-sectional neuroimaging and genetic study with unsupervised clustering that identifies distinct MDD subtypes and their cardiometabolic risk profiles, but lacks prospective validation, longitudinal follow-up, and independent replication needed to confirm clinical utility.

PromisingTryptophan and Brain Disorders B Vai E Maggioni

Reported

Cluster0 sample size2030

Cluster1 sample size1857

Between-cluster difference p-valuep<0.001

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