Tryptophan and Brain Disorders

SEP 10, 2026 · JOURNAL ARTICLE

The single-cell immune atlas of bacterial pneumonia: from inflammatory cell infiltration to treatable cell states

Frontiers in Cellular and Infection Microbiology

A narrative reorganization of published single-cell datasets proposing a ranked hypothesis framework for host-directed therapy targets in bacterial pneumonia, without new primary data, validation, or clinical outcome evidence.

SEP 10, 2026 · JOURNAL ARTICLE

PD-1 blockade exacerbates CD4+ T-cell dysregulation and dopaminergic neurodegeneration in Parkinson’s disease

Journal of Neuroinflammation

Mechanistic study in animal models demonstrating a pathway by which PD-1 blockade may worsen neurodegeneration, but no human clinical evidence or hard endpoints to support direct translation to patient care.

SEP 9, 2026 · JOURNAL ARTICLE

Integrative multi-omics profiling of insomnia-related molecular features reveals microbiome, immune, and therapy-relevant heterogeneity in colorectal cancer

Microbiology Spectrum

This is an exploratory multi-omics association study using unsupervised clustering to identify molecular subtypes linked to insomnia features in CRC; it raises mechanistic questions and generates a risk score but lacks prospective validation, a comparator arm, or hard clinical outcome data to support causal inference or clinical action.

SEP 8, 2026 · JOURNAL ARTICLE

Cooperation or Conflict? Molecular and Physiological Cross-Talk Between the Aryl Hydrocarbon and Vitamin D Receptors

Pharmaceuticals

A comprehensive mechanistic review synthesizing molecular and physiological evidence for cross-talk between two receptor pathways, raising questions about therapeutic translation rather than answering them with clinical evidence.

SEP 4, 2026 · JOURNAL ARTICLE

Integrated approaches to geriatric mental disorders: pathophysiology, interventions, and precision medicine horizons

Frontiers in Psychiatry

A comprehensive narrative review synthesizing evidence on geriatric mental disorder pathophysiology, management, and emerging approaches; provides clinical roadmap rather than new primary evidence.

SEP 3, 2026 · JOURNAL ARTICLE

Potential effects of kombucha on endoplasmic reticulum stress and weight regulation in a high-fat diet-induced obesity model

Nutrition and Health

Small single-center animal study with a primary finding (reduced weight gain) that lacks statistical significance testing and ER stress markers showing only numerical, non-significant reductions, requiring confirmation in larger cohorts.

SEP 1, 2026 · JOURNAL ARTICLE

664. From criteria to cure: definitions, immune targets, and adaptive treatment-trials in treatment-resistant depression

The International Journal of Neuropsychopharmacology

A consensus-based presentation of operational criteria for TRD and PRD, combined with a review of biological mechanisms and trial design innovations, intended to standardize definitions and inform future clinical research rather than report a primary empirical finding.

SEP 1, 2026 · JOURNAL ARTICLE

177. Korean medication algorithm project for depressive disorder 2025 (III): child and adolescent

The International Journal of Neuropsychopharmacology

Expert consensus-based treatment algorithm for pediatric depression, systematically revised through iterative survey methodology, providing actionable clinical recommendations without new primary efficacy data.