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Jie Liang

Second Affiliated Hospital of Zhejiang University

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SEP 10, 2026 · JOURNAL ARTICLE

PD-1 blockade exacerbates CD4+ T-cell dysregulation and dopaminergic neurodegeneration in Parkinson’s disease

Journal of Neuroinflammation

Mechanistic study in animal models demonstrating a pathway by which PD-1 blockade may worsen neurodegeneration, but no human clinical evidence or hard endpoints to support direct translation to patient care.

Hypothesis-GeneratingJie Liang Tryptophan and Brain Disorders Luyan Gu

Study details

DesignPreclinical mechanistic study in transgenic…

InterventionPD-1 blockade, PD-L1-Fc treatment, CD4+ T c…

ComparatorControl; PD-L1-Fc as reversal agent; CD4+ T…

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