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L Sforzini

King's College London

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SEP 1, 2026 · JOURNAL ARTICLE

664. From criteria to cure: definitions, immune targets, and adaptive treatment-trials in treatment-resistant depression

The International Journal of Neuropsychopharmacology

A consensus-based presentation of operational criteria for TRD and PRD, combined with a review of biological mechanisms and trial design innovations, intended to standardize definitions and inform future clinical research rather than report a primary empirical finding.

Expert GuidanceTryptophan and Brain Disorders Treatment of Major Depression L Sforzini

Study details

DesignConsensus guideline development (Delphi met…

InterventionOperational definitions for TRD and PRD; bi…

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