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Single-species mechanistic study using transcriptomics to explore molecular correlates of depressive-like phenotypes in mice; raises questions about habenular cell involvement but does not test a clinical intervention or establish causation in humans.
A single-centre, uncontrolled descriptive study of an animal model comparing obese and lean adolescent rats with anatomical and behavioural outcomes; no statistical comparisons, confidence intervals, or p-values reported.
Mechanistic study in a mouse model proposing a novel signaling pathway for clozapine-induced weight gain, without evidence of clinical translation or validation in humans.
The International Journal of Neuropsychopharmacology
Uncontrolled, preclinical study in a mouse depression model with a mechanistic focus; demonstrates proof-of-concept for ketamine metabolites restoring prosocial behaviors but requires human clinical validation.
Single-centre community sample with modest subgroup sizes after stratification, exploratory three-way interaction analysis, and surrogate endpoints (self-reported symptoms); authors acknowledge need for replication in larger cohorts.
A prospective longitudinal study with repeated measures showing significant improvements in depression, anxiety, suicidality and most cognitive domains during 6 months of abstinence, but limited by small sample size and single-centre setting.
A narrative review compiling known drug-TCTP interactions to propose repurposing opportunities; raises questions about therapeutic potential rather than testing clinical efficacy.
This is a narrative literature review synthesizing existing evidence on methamphetamine neurotoxicity and epidemiology, without new primary data, original analysis, or actionable clinical recommendations beyond restating known gaps.