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A single-centre, uncontrolled descriptive study of an animal model comparing obese and lean adolescent rats with anatomical and behavioural outcomes; no statistical comparisons, confidence intervals, or p-values reported.
Mechanistic study in a mouse model proposing a novel signaling pathway for clozapine-induced weight gain, without evidence of clinical translation or validation in humans.
Single-centre community sample with modest subgroup sizes after stratification, exploratory three-way interaction analysis, and surrogate endpoints (self-reported symptoms); authors acknowledge need for replication in larger cohorts.
A prospective longitudinal study with repeated measures showing significant improvements in depression, anxiety, suicidality and most cognitive domains during 6 months of abstinence, but limited by small sample size and single-centre setting.
A narrative review compiling known drug-TCTP interactions to propose repurposing opportunities; raises questions about therapeutic potential rather than testing clinical efficacy.
This is a narrative literature review synthesizing existing evidence on methamphetamine neurotoxicity and epidemiology, without new primary data, original analysis, or actionable clinical recommendations beyond restating known gaps.
An expert consensus meeting report that defines research priorities and recommendations for anhedonia assessment and treatment, rather than reporting primary empirical findings.
This is a perspective article proposing a mechanistic hypothesis about 5-HT4 receptor agonists in mood disorders, supported by preclinical evidence and epidemiological suggestion, but lacking clinical trial data demonstrating efficacy in humans with depression or anxiety.