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Neurotransmitter Receptor Influence on Behavior / Regulation of Appetite and Obesity · Journal article
Histochemistry and Cell Biology · September 6, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a descriptive animal study comparing dendritic architecture and locomotor activity in adolescent obese (ZDF) and lean (Long-Evans) rats, stratified by sex. The authors report shorter dendritic length and reduced dendritic spine density in both male and female obese rats, with female obese rats also showing decreased exploratory activity, but provide no statistical tests, effect sizes, or confidence intervals to support these claims.
Descriptive animal model comparison. Adolescent (60-day-old) obese Zucker diabetic fatty (ZDF) rats of both sexes and lean Long-Evans (LE) control rats.. Intervention: Obese ZDF rat phenotype (genetic model of obesity and diabetes). Compared with: Lean Long-Evans rats.
Female ZDF rats exhibited increased body weight, Lee index, and abdominal circumference compared to controls Male ZDF rats showed shorter body length alongside increased Lee index and abdominal circumference ZDF rats of both sexes displayed elevated triglyceride and cholesterol levels
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This is a preclinical animal study with unclear translational relevance to human adolescent obesity; dendritic morphology and open-field activity are mechanistic surrogate measures. Results cannot directly inform clinical practice without replication in humans or in a controlled trial design.
A single-centre, uncontrolled descriptive study of an animal model comparing obese and lean adolescent rats with anatomical and behavioural outcomes; no statistical comparisons, confidence intervals, or p-values reported.
As stated by the source record.
Quoted from the source exactly as published.
This is a preclinical animal study with unclear translational relevance to human adolescent obesity; dendritic morphology and open-field activity are mechanistic surrogate measures. Results cannot directly inform clinical practice without replication in humans or in a controlled trial design.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Abstract Obesity is a metabolic disorder characterized by the accumulation of excess body fat, which has been linked to skeletal muscle and motor behavior changes. Despite the high prevalence of obesity among children and adolescents in Mexico, it has mostly been studied using adult obese animal models. The objective of the present study was to analyze open-field locomotor activity and dendritic length and dendritic spine density in layer V pyramidal neurons of the primary motor cortex (M1) in adolescent (60-day-old) obese Zucker diabetic fatty (ZDF) rats of both sexes. Long-Evans (LE) rats were used as the control group. Female ZDF rats exhibited increased body weight, Lee index, and abdominal circumference. In contrast, male ZDF rats showed a shorter body length together with increased Lee index and abdominal circumference. However, ZDF rats of both sexes displayed elevated triglyceride and cholesterol levels. In addition, hyperglycemia was observed in male ZDF rats. Female ZDF rats showed decreased exploratory activity. The dendritic length of the basilar arbor of M1 neurons was significantly shorter in female and male ZDF rats, with ZDF males exhibiting a smaller basilar arbor than ZDF females. This last result was also observed in the apical arbor of these neurons. There was also a decrease in basilar and apical dendritic spine density in ZDF rats of both sexes. Our results indicate that female ZDF rats show alterations in exploratory behavior and dendritic arborization, whereas ZDF males are affected in terms of dendritic arborization in M1 neurons, which suggests sex differences in the effects of obesity in adolescent Zucker rats.
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