Molecular Therapy — Nucleic Acids

OCT 31, 2026 · JOURNAL ARTICLE

Expanding synthetic lethality through computationally designed aptamers

Molecular Therapy — Nucleic Acids

Aptamers are emerging as versatile tools in cancer research and therapy because they combine high target specificity with low immunogenicity, chemical tractability, and straightfor

SEP 29, 2026 · JOURNAL ARTICLE

Genome-wide CRISPRa screens identify modulators of CAR T survival across diverse tumor cytokine milieus

Molecular Therapy — Nucleic Acids

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of B cell malignancies, and extending this success to other cancers remains an urgent clinical objec

SEP 5, 2026 · JOURNAL ARTICLE

Engineering microRNAs as multimodal cancer therapeutics

Molecular Therapy — Nucleic Acids

This is a commentary describing a novel preclinical approach to engineer microRNAs as cancer therapeutics; it reports no original experimental data, effect sizes, or clinical outcomes.

AUG 28, 2026 · JOURNAL ARTICLE

Functional analysis of TTN uORFs reveals context-dependent translational regulation

Molecular Therapy — Nucleic Acids

Familial dilated cardiomyopathy (DCM) is a common condition with a high clinical burden, and no therapies that target the underlying genetic mechanisms. The leading genetic cause o

AUG 14, 2026 · JOURNAL ARTICLE

Next-generation macrophage engineering in cancer therapy: From TAM reprogramming to CAR-macrophages

Molecular Therapy — Nucleic Acids

This is a narrative review synthesizing mechanistic concepts and engineering strategies in preclinical macrophage biology, raising questions about feasibility rather than reporting clinical or definitive translational evidence.

JUL 21, 2026 · JOURNAL ARTICLE

Quieting the carrier: Matching delivery to immunology in anti-inflammatory mRNA therapy

Molecular Therapy — Nucleic Acids

A perspective or review article that raises conceptual questions about mRNA delivery platforms rather than reporting empirical evidence or clinical outcomes.