Cancer Research and Treatments

SEP 10, 2026 · REVIEW

Crosstalk between the microbiome and immune microenvironment in the pathogenesis and treatment of thyroid carcinoma: a narrative review

Frontiers in Immunology

A narrative review synthesizing mechanistic and exploratory literature on microbiome-immune interactions in thyroid cancer, raising questions about therapeutic targets rather than testing defined hypotheses with clinical outcomes.

SEP 10, 2026 · JOURNAL ARTICLE

Beyond Conventional PDOs: Organoids for Tumorigenesis for Gut Cancer Modeling and Fast Clinical Decision

Gut Medicine

A perspective review raising questions about organoid models for cancer rather than reporting empirical results, mechanistic findings, or clinical outcomes with measured effect sizes.

SEP 10, 2026 · JOURNAL ARTICLE

CRISPR-Cas9‑based lipid nanocarriers for advanced therapy of urinary bladder cancer

Nanomedicine

This is a narrative review of CRISPR-Cas9 delivery concepts for bladder cancer therapy with no original experimental data, clinical trial results, or comparative evidence.

SEP 9, 2026 · JOURNAL ARTICLE

Deep and durable response to re-challenge with platinum-based therapy in a platinum-relapsed small cell lung cancer patient following Olvi-Vec oncolytic immunotherapy: a case report

Frontiers in Oncology

A single-case report from an ongoing Phase Ib trial describing one patient's response; while the outcome is noteworthy, case reports lack comparison groups and generalizability to support clinical practice change.

SEP 9, 2026 · JOURNAL ARTICLE

A dual-site oral nanovaccine programs anti-colorectal tumor immunity from small intestinal priming to large intestinal boosting

Nature Communications

This is a mechanistic proof-of-concept study in a preclinical model demonstrating a novel nanovaccine strategy; it lacks human data, phase classification, or clinical endpoints needed for stronger evidence grading.

SEP 9, 2026 · JOURNAL ARTICLE

A Manganese-Chlorella Hydrogel for an Integrated “Remove–Remodel–Repair” Strategy in Pancreatic Cancer Therapy

Nano-micro Letters

This is a preclinical proof-of-concept study of a novel hydrogel material tested in vitro and in animal models, demonstrating feasibility but lacking human clinical data or comparison to standard therapy.

SEP 9, 2026 · JOURNAL ARTICLE

Glycolipid metabolic crosstalk in tumor immune evasion and therapeutic targeting

Discover Oncology

This is a narrative review proposing an integrated conceptual framework linking glycolipid metabolism to immune evasion, raising mechanistic questions rather than presenting empirical evidence from primary studies.

SEP 9, 2026 · JOURNAL ARTICLE

Escherichia coli Nissle 1917 in Cancer Bacteriotherapy: Functional Applications and Translational Challenges

Russian Journal of Bioorganic Chemistry

This is a narrative review that synthesizes existing evidence on a bacterial platform rather than presenting new experimental or clinical data, raising questions about translational potential without definitive answers.