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A single case report describing a technical maneuver to enable safe microwave ablation in an anatomically variant patient; demonstrates feasibility but lacks comparative data or outcomes from a case series.
Large population-based retrospective administrative study with robust sample size and clear epidemiologic findings, but uses diagnostic coding and medication dispensation as case identification without clinical validation, limiting causal inference and generalizability beyond Brazil's public system.
A single clinical case report with autopsy findings that illustrates a rare disease presentation; descriptive evidence useful for differential diagnosis but without comparative or interventional data.
Retrospective observational study without causal inference; primary associations become non-significant after adjustment for confounders, limiting clinical actionability.
A single-centre retrospective analysis of a prospectively maintained database showing that CA 19-9 surveillance detects recurrence in gallbladder cancer with modest sensitivity (45.6% for serial rise) and high specificity (95.3%), with a median lead time of 5.4 weeks before radiological detection.
A multicenter retrospective study showing improved survival and response rates with triple-combination therapy in advanced ICC, but limited by non-randomized design and moderate sample size that requires prospective confirmation.
Small retrospective single-centre cohort (n=26) with exploratory design and no powered comparisons; establishes real-world tolerability and PFS data but lacks control group and prospective validation.
Large retrospective cohort documenting epidemiological trends and surgical outcomes in pediatric cholelithiasis, with multivariable analysis of risk factors; confirms shifting disease patterns toward obesity-related etiology and validates laparoscopic approach efficacy.