Liver Diseases and Immunity

SEP 7, 2026 · JOURNAL ARTICLE

Immunotherapy in advanced biliary tract cancer: current status and future directions

Frontiers in Pharmacology

A narrative review synthesizing current evidence on immunotherapy in advanced biliary tract cancer, highlighting established standards (TOPAZ-1, KEYNOTE-966), emerging biomarkers, and investigational approaches rather than reporting original trial results.

SEP 4, 2026 · JOURNAL ARTICLE

Mechanism-Oriented Model Selection in MASH Research: Insights from the iHFC Diet and TSOD/TSNO Mice

Livers

This is a mechanistic review proposing a framework for model selection in MASH research; it raises questions about which experimental systems best interrogate specific biological pathways rather than testing a defined clinical hypothesis with empirical data.

SEP 1, 2026 · JOURNAL ARTICLE

Temporal trends in the epidemiology of primary biliary cholangitis in the public healthcare system of Brazil: a large population-based study

The Lancet Regional Health - Americas

Large population-based retrospective administrative study with robust sample size and clear epidemiologic findings, but uses diagnostic coding and medication dispensation as case identification without clinical validation, limiting causal inference and generalizability beyond Brazil's public system.

SEP 1, 2026 · JOURNAL ARTICLE

Severe chronic neutrophilic cholangiohepatitis with massive choledocholithiasis and hepatolithiasis in a pony

Equine Veterinary Education

A single clinical case report with autopsy findings that illustrates a rare disease presentation; descriptive evidence useful for differential diagnosis but without comparative or interventional data.

AUG 13, 2026 · JOURNAL ARTICLE

The menopause-obesity axis in MASH progression: from estrogen decline to liver fibrosis

Frontiers in Gastroenterology

This is a narrative review synthesizing mechanistic pathways and existing evidence rather than presenting original clinical data or trial results, raising questions about the menopause-obesity-MASH axis rather than answering them with new evidence.

AUG 11, 2026 · JOURNAL ARTICLE

Dietary patterns and their relationship with hepatobiliary health in patients with nonalcoholic fatty liver disease and gallstone disease

Frontiers in Nutrition

Retrospective observational study without causal inference; primary associations become non-significant after adjustment for confounders, limiting clinical actionability.

AUG 10, 2026 · JOURNAL ARTICLE

Efficacy and safety of sintilimab and lenvatinib combined with locoregional therapy as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter cohort study

Cancer Immunology Immunotherapy

A multicenter retrospective study showing improved survival and response rates with triple-combination therapy in advanced ICC, but limited by non-randomized design and moderate sample size that requires prospective confirmation.

AUG 9, 2026 · JOURNAL ARTICLE

Real-World Efficacy and Safety of Gemcitabine, Cisplatin, Plus Immune Checkpoint Inhibitors in Biliary Tract Cancer: A Retrospective Analysis

Cancers

Small retrospective single-centre cohort (n=26) with exploratory design and no powered comparisons; establishes real-world tolerability and PFS data but lacks control group and prospective validation.