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International Journal of Medical Science in Clinical Research and Review
Single-centre, uncontrolled observational study in a small sample (n=50) describing prevalence and associations without a comparator group, establishing feasibility but requiring confirmation in larger, comparative designs.
International Journal of Medical Science in Clinical Research and Review
Single-centre observational study with modest sample size (n=50) and cross-sectional design, showing associations between metabolic syndrome and hepatic steatosis in postmenopausal women but lacking a comparator group and unable to establish causation.
A prospective observational cohort showing that mild transaminase elevation during allopurinol therapy does not worsen and does not require dose interruption; sound method but limited by single-centre design, lack of control group, and modest sample size.
This is a mechanistic study in a single animal model without human data, showing pathway elucidation rather than clinical evidence of efficacy or safety.
A narrative review synthesizing pathogenic mechanisms and clinical relationships of MASLD with metabolic syndrome, offering conceptual framework rather than new empirical evidence.
Large retrospective cohort study from a national database with rigorous multivariable adjustment, reporting hard clinical endpoints (mortality, MI, stroke) with narrow confidence intervals and highly significant p-values across multiple cardiovascular outcomes.
A narrative review synthesizing current evidence on gut microbiota's role in NAFLD/MASLD pathogenesis, offering a functional framework for understanding dysbiosis and identifying gaps in clinical translation.
This is a mechanistic review proposing a framework for model selection in MASH research; it raises questions about which experimental systems best interrogate specific biological pathways rather than testing a defined clinical hypothesis with empirical data.