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A well-designed cross-sectional study dissecting independent and interactive effects of obesity and COVID-19 severity on immune mediators and cell populations, with rigorous statistical approach, but limited by lack of longitudinal follow-up, hard clinical outcomes, or external validation of biomarker utility.
Animal model study with mechanistic findings on arrhythmia reduction; lacks human validation and hard clinical outcomes needed for stronger evidence grading.
This is a narrative review summarizing existing evidence and proposing intrapancreatic fat as a biologically plausible mediator of pancreatic cancer risk, rather than presenting primary empirical evidence or a definitive causal relationship.
A narrative review synthesizing current evidence on AI applications in cardiovascular prevention, addressing implementation gaps and future requirements rather than reporting original trial results.
A narrative review synthesizing diagnostic approaches and prognostic implications for atrial cardiomyopathy, providing expert recommendations on evaluation methods and their clinical utility.
In vitro mechanistic study establishing an exploratory model of adipose-liver communication via extracellular vesicles; raises questions about EV-mediated metabolic signaling but does not measure clinical outcomes or hard endpoints.
Turk Kardiyoloji Dernegi Arsivi-archives of the Turkish Society of Cardiology
Prospective comparative cohort study with standardized cardiac imaging and multivariable analysis demonstrating significant structural and functional reverse remodeling after bariatric surgery, with differential effects between procedures and mechanistic insights.