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Min Young Lee

Seoul National University

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SEP 10, 2026 · JOURNAL ARTICLE

UCP1 neddylation regulates white adipocyte browning through NIX-mediated mitophagy

Cell Communication and Signaling

Mechanistic study in cell culture and animal models identifying a post-translational regulatory pathway; lacks human data, hard clinical outcomes, or phase clinical trial evidence needed to support clinical translation.

Hypothesis-GeneratingCardiovascular Disease and Adiposity Min Young Lee Jong-Wan Park

Reported

Primary regulatory mechanism iden…Dual-site neddylation (K138, K237) by MDM2

Intervention agentMLN4924

Study modelHFD-induced obese Ucp1+/+ and Ucp1−/− mice…

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