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Cholangiocarcinoma and Gallbladder Cancer Studies / Gallbladder and Bile Duct Disorders · Journal article
Journal of Surgical Oncology · August 10, 2026
Encouraging direction, but not yet definitive.
This retrospective single-centre cohort of 813 post-resection gallbladder cancer patients shows that serial CA 19-9 elevation achieves 95.3% specificity but only 45.6% sensitivity for detecting recurrence, with a median 5.4-week lead time over radiological detection. The modest sensitivity limits standalone utility, though high specificity suggests serial rise warrants further investigation in this high-risk population.
Retrospective cohort analysis of prospectively maintained database. Patients undergoing curative-intent resection for gallbladder cancer at Tata Memorial Hospital, India, between 2010 and 2024.. Intervention: Postoperative serum CA 19-9 surveillance with serial measurements. Compared with: Clinico-radiological detection of recurrence. n = 813. Tata Memorial Hospital, India.
Among 327 patients with recurrence (40.2% of 813), 210 (64.2%) had postoperative CA 19-9 rise First raised CA 19-9 value (>37 U/mL): 64.5% sensitivity, 89.3% specificity, AUC = 0.681 Serial rise in CA 19-9: 45.6% sensitivity, 95.3% specificity
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
CA 19-9 surveillance offers high specificity but limited sensitivity for recurrence detection; serial rise should prompt urgent imaging in post-resection GBC patients. The 5.4-week lead time over radiological detection may permit earlier systemic intervention, though approximately 36% of recurrences will be missed by CA 19-9 monitoring alone.
A single-centre retrospective analysis of a prospectively maintained database showing that CA 19-9 surveillance detects recurrence in gallbladder cancer with modest sensitivity (45.6% for serial rise) and high specificity (95.3%), with a median lead time of 5.4 weeks before radiological detection.
As stated by the source record.
Quoted from the source exactly as published.
CA 19-9 surveillance offers high specificity but limited sensitivity for recurrence detection; serial rise should prompt urgent imaging in post-resection GBC patients. The 5.4-week lead time over radiological detection may permit earlier systemic intervention, though approximately 36% of recurrences will be missed by CA 19-9 monitoring alone.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
ABSTRACT Background Gallbladder cancer (GBC) is the most common biliary tract malignancy with aggressive biology and poor outcomes. Early detection of recurrence after curative resection is crucial to enable timely systemic therapy. This study evaluates role of Carbohydrate Antigen 19‐9 (CA 19‐9) surveillance in detecting recurrence after radical surgery for GBC. Material and Methods Retrospective analysis of a prospectively maintained database was conducted at Tata Memorial Hospital, India, between 2010 and 2024. Patients undergoing curative‐intent resection for GBC were included. Postoperative CA 19‐9 trends, including first elevated value and serial rise were analyzed to detect recurrence. Results A total of 813 patients were analyzed; 327 (40.2%) developed recurrence. Among them, 210 (64.2%) had a postoperative CA19‐9 rise. Fifty‐three patients had CA 19‐9 elevation without clinico‐radiological recurrence. A first raised CA 19‐9 value (> 37 U/mL) predicted recurrence with 64.5% sensitivity, 89.3% specificity (AUC = 0.681). A serial rise in CA 19‐9 value yielded 45.6% sensitivity and 95.3% specificity. The median duration between first raised CA 19‐9 value and radiological detection of recurrence was 5.4 weeks. Conclusions Serum CA 19‐9 surveillance detects early recurrences in resected GBCs with modest sensitivity and specificity. Serial rise in CA 19‐9 should prompt more detailed investigations to detect recurrence.
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