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A single case report integrated with bibliometric review and exploratory bioinformatic analysis of gene expression datasets; no clinical trial, no new diagnostic or therapeutic validation, and no quantitative evidence of intervention efficacy beyond one patient's response.
A two-patient retrospective case series with mixed responses (one PR, one SD) in a heavily pretreated population; descriptive observations that generate hypotheses rather than test them and are explicitly insufficient to demonstrate efficacy or resistance reversal.