Inflammasome and Immune Disorders

SEP 8, 2026 · JOURNAL ARTICLE

Anticancer Effect of Dendrosome Nanocurcumin plus LL-37 Antimicrobial Peptide against Colorectal Cancer Cells in vitro and in vivo

Bangladesh Journal of Infectious Diseases

Early-phase in vitro and in vivo mechanistic study in animal models with surrogate endpoints (gene expression and apoptosis markers); lacks human data, clinical outcomes, and adequate statistical reporting to support clinical translation.

SEP 7, 2026 · JOURNAL ARTICLE

When Lowering LDL Is Not Enough: Confronting Residual Inflammatory Risk After Myocardial Infarction

Korean Circulation Journal

A single-centre observational study with serial biomarker measurements demonstrating a clear association between residual inflammatory risk and clinical outcomes in post-MI patients, but lacking a randomized design or intervention to establish causation or guide treatment.

SEP 7, 2026 · JOURNAL ARTICLE

Context-dependent roles of the NLRP3 inflammasome in osteomyelitis and strategies for precision modulation

Frontiers in Immunology

This is a mechanistic review synthesizing existing knowledge about NLRP3 inflammasome roles in osteomyelitis pathogenesis and proposing therapeutic strategies, without reporting new experimental or clinical trial data.

SEP 4, 2026 · JOURNAL ARTICLE

PANoptosis-related HLTF promotes prostate cancer progression and serves as a potential therapeutic target

BMC Cancer

Early-stage mechanistic study combining bioinformatics clustering, cell-line experiments, and computational docking without clinical validation or in vivo efficacy data for proposed HLTF-targeting interventions.

SEP 3, 2026 · JOURNAL ARTICLE

Metabolic-microbial crosstalk drives inflammasome activation: fasn and palmitoylation mediate palmitate-Porphyromonas gingivalis synergy in macrophage-like cells

Scientific Reports

In vitro mechanistic study in cell culture identifying a potential metabolic-microbial interaction pathway; lacks clinical validation, animal models, or hard endpoints needed to guide practice.

AUG 25, 2026 · JOURNAL ARTICLE

Plant-derived exosome-like nanoparticles from traditional Chinese medicine herbs: A nanobiological framework for antimicrobial phytochemical delivery

Next Nanotechnology

This is a narrative review synthesizing preclinical mechanistic evidence and proposing a theoretical framework; it does not report primary experimental data, clinical outcomes, or comparative efficacy studies.

AUG 18, 2026 · JOURNAL ARTICLE

A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway

Science Signaling

Genome-wide CRISPR screening in cell lines identifies candidate genes regulating interferon induction, providing mechanistic insights and a resource for future studies but not clinical evidence of efficacy or causation in disease.

AUG 14, 2026 · JOURNAL ARTICLE

GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors

Pharmacological Research

Mechanistic study identifying GSDME-mediated pyroptosis as a determinant of proteasome inhibitor efficacy, supported by multiple tumor models and human correlative data, but lacks prospective clinical trials or hard clinical outcomes.