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A cross-sectional analysis in a large nationally representative sample showing an inverse association between serum magnesium and MASLD with statistical significance, but limited by observational design and inability to establish causation.
A comprehensive pan-cancer bioinformatic and expression profiling study identifying TACSTD2 as a potential biomarker and therapeutic target, but lacking clinical validation or mechanistic proof of causation.
This is a narrative review synthesizing preclinical mechanistic evidence and theoretical frameworks for calcium-mediated vascular disruption in cancer, without reporting new experimental or clinical data, efficacy endpoints, or comparative trials.
Single-centre, small prospective cross-sectional study (n=53) with no comparator group; describes prevalence of renal findings in an obese population but lacks the design rigour and sample size to establish causation or guide practice change.
Cross-sectional observational study demonstrating associations between vitamin D, chemerin, and metabolic syndrome in type 2 diabetes, but lacking causal inference, longitudinal follow-up, and independent predictive value in adjusted models.
Cross-sectional study with adequate sample size demonstrating independent association between insulin resistance and trabecular bone quality (not density) in obesity; mechanistic insight but no intervention or longitudinal outcome data.
This is a narrative review summarizing current disease-modifying therapies for ATTRv-PN, comparing mechanisms and clinical evidence to guide clinical practice, rather than reporting original research findings.