Loading
Magnesium in Health and Disease / Parathyroid Disorders and Treatments · Journal article
Metabolites · August 18, 2026
Encouraging direction, but not yet definitive.
This cross-sectional study of 4952 Korean adults found an inverse association between serum magnesium levels and metabolic dysfunction-associated steatotic liver disease (MASLD), with a statistically significant odds ratio of 0.90 per 1-SD increment in serum magnesium after adjustment for sociodemographic factors. The finding is based on observational data and does not establish causal relationship or directionality.
Cross-sectional study. Adults in South Korea; nationally representative sample. Intervention: Serum magnesium level (observational; no intervention applied). Compared with: MASLD presence versus absence. n = 4,952. South Korea.
Mean serum Mg level was 2.13 (0.15) mg/dL in the study population Prevalence of MASLD was 25.7% in the sample OR for MASLD per 1-SD increment in serum Mg was 0.90 (95% CI 0.84–0.96, p = 0.004)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
While the inverse association between magnesium and MASLD is statistically significant and plausible, the cross-sectional design prevents drawing causal conclusions. This finding warrants prospective or interventional studies before clinical recommendations on magnesium supplementation for MASLD prevention can be made.
A cross-sectional analysis in a large nationally representative sample showing an inverse association between serum magnesium and MASLD with statistical significance, but limited by observational design and inability to establish causation.
As stated by the source record.
Quoted from the source exactly as published.
While the inverse association between magnesium and MASLD is statistically significant and plausible, the cross-sectional design prevents drawing causal conclusions. This finding warrants prospective or interventional studies before clinical recommendations on magnesium supplementation for MASLD prevention can be made.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background/Objectives: Magnesium (Mg) deficiency has been linked to various adverse health outcomes; however, its association with metabolic dysfunction-associated steatotic liver disease (MASLD) has not been fully elucidated. This study examined the association of serum Mg levels with MASLD in Korean adults. Methods: We analyzed a nationwide sample of 4952 adults in South Korea. Serum Mg levels (mg/dL) were measured. MASLD was defined as a hepatic steatosis index score of ≥36 together with the presence of cardiometabolic risk factor, including overweight/obesity, high fasting glucose, high blood pressure, high plasma triglycerides, or low plasma HDL cholesterol. The association between serum Mg levels and MASLD was examined using logistic regressions. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined. Results: The mean (standard deviation [SD]) serum Mg level was 2.13 (0.15) mg/dL. The prevalence of MASLD was 25.7%. After adjusting for the sociodemographic variables, the OR (95% CI) for the association between a 1–SD increment in serum Mg levels and MASLD was 0.90 (0.84–0.96, p = 0.004). Conclusions: This nationally representative cross-sectional study found that serum Mg levels were inversely associated with the likelihood of MASLD among adults in South Korea.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.