INTRODUCTION: The PRODIGE 24/CCTG PA.6- trial has shown an overall survival (OS) up to 55 months in patients treated with (modified) 5-fluorouracil, leucovorin, irinotecan and oxal
ABSTRACT Background Multimodal therapy (MMT) combining surgery and chemotherapy remains the optimal management strategy irrespective of sequence for resectable pancreatic ductal ad
Large, well-powered observational cohort study from a national database demonstrating superior survival with adjuvant versus perioperative chemotherapy in cT2N0 gastric cancer, with multivariable analysis and clear effect sizes, though observational design limits causal inference.
A single-centre retrospective analysis of a prospectively maintained database showing that CA 19-9 surveillance detects recurrence in gallbladder cancer with modest sensitivity (45.6% for serial rise) and high specificity (95.3%), with a median lead time of 5.4 weeks before radiological detection.