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Journal of Surgical Oncology

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AUG 16, 2026 · JOURNAL ARTICLE

Optimal Management of Clinical T2N0 Gastric Adenocarcinoma: Surgery or Chemotherapy First?

Journal of Surgical Oncology

Large, well-powered observational cohort study from a national database demonstrating superior survival with adjuvant versus perioperative chemotherapy in cT2N0 gastric cancer, with multivariable analysis and clear effect sizes, though observational design limits causal inference.

Strong EvidenceMatthew Dixon Elizabeth J. Olecki Esophageal Cancer Research and Treatment

Reported

Sample size (total)3676

Sample size (upfront surgery)2961

Hazard ratio (perioperative chemo…0.64

AUG 10, 2026 · JOURNAL ARTICLE

The Role of Serial Serum Carbohydrate Antigen 19‐9 Surveillance to Detect Recurrences after Curative Resection for Gallbladder Carcinoma

Journal of Surgical Oncology

A single-centre retrospective analysis of a prospectively maintained database showing that CA 19-9 surveillance detects recurrence in gallbladder cancer with modest sensitivity (45.6% for serial rise) and high specificity (95.3%), with a median lead time of 5.4 weeks before radiological detection.

PromisingCholangiocarcinoma and Gallbladder Cancer Studies Shraddha Patkar Dr.Faisal Abdul Mujeeb

Reported

Sample size813

Recurrence rate327/813 (40.2%)

CA 19-9 elevation among recurrenc…210/327 (64.2%)