Jci Insight

OCT 22, 2026 · JOURNAL ARTICLE

STING agonism orchestrates myeloid-predominant tumor necrosis preceding T cell-dependent regression in osteosarcoma

Jci Insight

An immunosuppressive, macrophage-rich tumor microenvironment (TME) is a barrier to immunotherapy across many cancers including osteosarcoma, where immunotherapy has largely failed.

OCT 20, 2026 · JOURNAL ARTICLE

Defective Vδ2+ T cell metabolic and functional responses in obesity are reversed with bariatric surgery

Jci Insight

Obesity is a chronic progressive disease strongly linked to numerous comorbidities. This is underpinned by a chronic inflammatory environment and significant immune dysregulation.

OCT 7, 2026 · JOURNAL ARTICLE

177Lu-labeled DOTA-EB-RGD as a candidate for thyroid cancer therapy

Jci Insight

Integrin α V β 3, a transmembrane receptor involved in tumor growth and metastasis, specifically recognizes and binds proteins with the Arg-Gly-Asp (RGD) peptide sequence. Using mR

OCT 6, 2026 · JOURNAL ARTICLE

Anti-CRF antibody-mediated HPA axis modulation induces selective fat mass loss with lean mass preservation

Jci Insight

The hypothalamic-pituitary-adrenal (HPA) axis integrates central neural processing and responses to stress with endocrine and metabolic responses. We utilized a monoclonal antibody

OCT 6, 2026 · JOURNAL ARTICLE

Targeting HSPA1A with geranylgeranylacetone alleviates ADTKD-UMOD via suppression of endoplasmic reticulum stress and ferroptosis

Jci Insight

Missense mutations in the UMOD gene are a well-established genetic cause of autosomal dominant tubulointerstitial kidney disease (ADTKD). Here, we report two ADTKD pedigrees carryi

SEP 29, 2026 · JOURNAL ARTICLE

Anti-Notch plus endocrine therapy in ER+ breast cancer inhibits cancer stem cells by increasing DAXX

Jci Insight

Resistance to endocrine therapy (ET) in ER + breast cancer is mediated by Notch signaling, but the clinical application of anti-Notch therapy has been limited by the lack of predic

SEP 7, 2026 · JOURNAL ARTICLE

Estrogen promotes tumor phenotypes in ER+ and ER– breast cancer through UGDH-GPR30

Jci Insight

This is a mechanistic study using cell lines, animal models, and patient specimens to explore a signaling pathway; it raises questions about UGDH/GPR30 in estrogen-responsive breast cancer but does not report clinical outcomes or hard endpoints that would support practice change.

AUG 10, 2026 · JOURNAL ARTICLE

Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS

Jci Insight

A mechanistically detailed transcriptomic study in a modest patient cohort identifying a potential pathway (SLIT2/ROBO signaling) that impairs adipogenesis in PCOS, supported by targeted cell culture validation but requiring confirmation in larger cohorts and functional studies.